FERM And PDZ Domain Containing Protein 3 (FRMPD3)

FRMPD3, Contains 1 FERM domain. Contains 1 PDZ (DHR) domain. The general organization and positioning of the PDZ and FERM domains in Frmpd1 is also found in Frmpd3 and Frmpd4 as determined with the Simple Modular Architecture Research Tool (SMART). Human Frmpd1 exhibits 19 and 21% overall amino acid identity to Frmpd3 and Frmpd4, respectively. Human Frmpd3 and Frmpd4 exhibit 24% overall amino acid identity with each other. The amino-terminal 500 amino acids containing the PDZ and FERM domains in Frmpd1 exhibit 33 and 41% amino acid identity with Frmpd3 and Frmpd4, respectively, whereas Frmpd3 and Frmpd4 exhibit 44% homology in this region. Frmpd2 is more representative of a separate group of proteins with PDZ and FERM domains that differ from group I by the number and position of the PDZ domain(s) .