FERM And PDZ Domain Containing Protein 4 (FRMPD4)

FRMPD4 encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins, it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.The general organization and positioning of the PDZ and FERM domains in Frmpd1 is also found in Frmpd3 and Frmpd4 as determined with the Simple Modular Architecture Research Tool. Human Frmpd1 exhibits 19 and 21% overall amino acid identity to Frmpd3 and Frmpd4, respectively. The amino-terminal 500 amino acids containing the PDZ and FERM domains in Frmpd1 exhibit 33 and 41% amino acid identity with Frmpd3 and Frmpd4, respectively, whereas Frmpd3 and Frmpd4 exhibit 44% homology in this region.