FERM Domain Containing Protein 8 (FRMD8)

FRMD8 Contains 1 FERM domain. FERM domain Also: ERM homology domain, named after the proteins in which this domain was observed first. The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins contain a C-terminal F-actin binding segment and a conserved N-terminal FERM domain that functions as a common membrane binding module by directly interacting with the cytoplasmic domains of integral membrane proteins.In some proteins containing a FERM domain the FERM domain can associate with other regions of the protein and block binding or phosphorylation sites, thus regulating protein activities.The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane.