FERM, RhoGEF And Pleckstrin Domain Containing Protein 1 (FARP1)

FARP1 was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.The cDNA encoded a 1,045-amino acid protein sequence containing an ezrin-like domain, a Dbl homology (DH) domain, and a pleckstrin homology (PH) domain. Northern blot analysis revealed that the gene is expressed as 3.5- and 5.0-kb mRNAs in a variety of embryonic and adult human tissues.