FEZ Family Zinc Finger Protein 1 (FEZF1)

ZNF312B was overexpressed in human gastric cancer tissues and cell lines. Overexpression of ZNF312B induced accelerated proliferation in cultured cells and increased tumor mass in nude mice. ZNF312B translocated to the nucleus via its C-terminal proline-rich domain, and nuclear ZNF312B induced KRAS overexpression, resulting in activation of ERK signaling. The 475-amino acid human FEZF1 protein, which they called ZNF312B, contains 6 C2H2-type zinc finger domains in its C-terminal half and a proline-rich motif near its C terminus. It shares 55% amino acid identity with ZNF312 (FEZF2). Using immunohistochemical analysis, Song et al. (2009) found that ZNF312B showed nuclear expression in a transfected human gastric cancer cell line.