Family With Sequence Similarity 134, Member B (FAM134B)

Structure analysis showed that the N-terminal half of FAM134B has 2 unusually long hydrophobic segments of about 35 amino acids each that are separated by a hydrophilic loop of about 60 amino acids. This structure is similar to that of reticulon proteins that shape the curvature of endoplasmic reticulum membranes. The C terminus of FAM134B contains a coiled-coil domain. Northern blot analysis of adult mouse tissues detected at least 4 Fam134b transcripts. High expression of an approximately 1.5-kb transcript was detected in testis only. Transcripts of about 3.5 kb were more weakly expressed in dorsal root ganglia, esophagus, skeletal muscle, and kidney, and many other tissues showed much weaker Fam134b expression. In situ hybridization of day-14.5 mouse embryos showed prominent staining of sensory and autonomic ganglia.