Family With Sequence Similarity 175, Member B (FAM175B)

In a bioinformatics analysis to reveal proteins related to Abraxas (ABRA1), Wang et al. (2007) identified the KIAA0157 protein (Nagase et al., 1995). The 415-amino acid protein, which Wang et al. (2007) designated ABRO1 for """Abraxas brother-1,""" shares 39% identity to ABRA1 in the N-terminal two-thirds of the protein (amino acids 1 to 260), including a coiled-coil domain and a region called the ABR domain. However, ABRO1 lacks the phosphorylated ser-X-X-phe motif of ABRA1 and, unlike ABRA1, does not bind to BRCA1 .By PCR of a panel of human-rodent hybrid cell lines, Nagase et al. (1995) mapped the FAM175B gene to chromosome 10.