Family With Sequence Similarity 3, Member A (FAM3A)

Three-dimensional modeling indicated that 4 cysteines could form 2 disulfide bonds linking helices 1 and 4 and helices 2 and 3. Northern blot analysis detected FAM3A expression in almost all tissues tested. Immunohistochemical analysis of mouse tissues detected prominent Fam3a staining in capillary endothelium and endocardium of heart, as well as vascular endothelial staining in many other tissues. Staining was also seen in mouse pancreatic islets and ductal epithelium, in the epithelium of seminal vesicles, prostate, and epididymis, in the acrosome of spermatids, in the epithelium of oviducts and endometrium, in distal nephron, urinary bladder, and biliary tract, and in macrophages, stromal cells, fibroblasts, and adipocytes in loose connective tissue surrounding several organs.