Family With Sequence Similarity 46, Member C (FAM46C)

FAM46C is a protein of unknown function consisting of 391 amino acid residues that are translated from an mRNA consisting of 5720 base pairs. FAM46C was initially sequenced as part of the Full-length long Japan genomic sequencing project. FAM46C is found on chromosome 1 at the locus 1p12 FAM46C contains one domain of unknown function, DUF1693, and as such has been placed in the DUF1693 protein family. This protein family has been established as a part of the Nucleotidyltransferase superfamily[1] and contains 4 nematode prion-like proteins. FAM46C was placed into group XXV of the nucleotidyltransferase superfamily[1] along with 3 other Homo sapiens FAM46 proteins (A, B, D). It has been suggested that FAM46C may be functionally involved with the Type 1 interferon response.