Family With Sequence Similarity 48, Member A (FAM48A)

p38IP, contains 2 C-terminal serine-rich domains. The transcript contains a short upstream ORF and a major ORF that encodes a deduced 733-amino acid protein with a calculated molecular mass of 80 kD. The protein has an N-terminal nuclear targeting signal, followed by an alpha helix-rich domain, a PEST motif, and a C-terminal glutamine cluster. It also has several potential serine phosphorylation sites. Northern blot analysis detected transcripts of 3.0 and 4.4 kb in all tissues examined. Northern blot and expression array analyses showed highest expression in testis, followed by various adult brain regions and several fetal tissues, including lung, brain, spleen, thymus, and kidney. In situ hybridization of normal human prostate detected FAM48A mainly in the epithelium.