Family With Sequence Similarity 82, Member A1 (FAM82A1)

By database searching, Oishi et al. (2007) identified 3 human proteins related to a family of microtubule-associated proteins in C. elegans: RMD1, RMD2, and RMD3. The deduced proteins in both species contain multiple coiled-coil domains and localize to spindle microtubules and spindle poles during cell division. In interphase, the human RMD proteins localized to the cytoplasm, with some staining in the microtubule lattice. RMD2 was also observed in the perinuclear region.Using cosedimentation assays, Oishi et al. (2007) showed that human RMD1, RMD2, and RMD3 proteins interact with microtubules.Scott (2008) mapped the FAM82A gene to chromosome 2p22.2 based on an alignment of the FAM82A sequence with the genomic sequence.