Family With Sequence Similarity 83, Member B (FAM83B)

FAM83B belongs to the FAM83 family. The human FAM83 family of genes is comprised of 8 members: designated FAM83A through FAM83H. Fam83h is the largest; Fam83a is the smallest. Alignment of the human Fam83 proteins shows that homology common to the entire group begins near the N-terminus and ends at Ser281. This conserved N-terminal region also corresponds closely to the part of Fam83h that is included in conserved domain database (CDD) for the phospholipase D (PLD) superfamily. The homology with PLD however is trace, and may be indicative of a conserved three-dimensional fold. The N-terminal domain that shows trace similarity to PLD bears much greater resemblance to the other members of the FAM83 family and is the shared element that gives the group its identity.