Forkhead Box D4 Like Protein 3 (FOXD4L3)

FOX (Forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development.The defining feature of FOX proteins is the forkhead box, a sequence of 80 to 100 amino acids forming a motif that binds to DNA. By examining genes arising from intra- and interchromosomal duplications involving the ancestral chromosome 2 fusion site, Fan et al. (2002) identified FOXD4L1, FOXD4L2, and FOXD4L3. The deduced 417-amino acid FOXD4L3 protein contains a central forkhead domain.Fan et al. (2002) determined that FOXD4L3 is a single-exon gene, and they identified a TATA box in the promoter region.By genomic sequence analysis, Fan et al. (2002) mapped the FOXD4L3 gene to chromosome 9q13.