Forkhead Box Protein D2 (FOXD2)

The conceptual translation product predicts a protein of 372 amino acids within an N-terminal domain rich in acidic amino acids and with a high likelihood of forming an amphipathic helix, a DNA binding forkhead domain, and a C-terminal region that has a high probability of forming an amphipathic beta-sheet. The amino acid sequence of the DNA binding forkhead motif of this protein is identical to that of another forkhead protein, FREAC4, whereas 12 substitutions are present at the nucleotide level. There are no similarities in regions outside of the DNA binding domains of FREAC9 and FREAC4, and since the gene encoding the latter protein maps to 5q12-q13, it is likely that evolutionary selection has acted to maintain identical DNA binding domains between these 2 kidney-expressed transcription factors.