Forkhead Box Protein E1 (FOXE1)

FOXE1 belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.The predicted 376-amino acid FKHL15 protein contains a 19-residue polyalanine tract and 2 putative nuclear localization signals which flank the forkhead domain. Northern blot analysis detected a single 4.5-kb FKHL15 mRNA in a variety of tissues and multiple FKHL15 transcripts in others.