Forkhead Box Protein F1 (FOXF1)

FOXF1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.The predicted 354-amino acid protein is nearly identical to FREAC2 (FKHL6) within a 112-residue region containing the forkhead domain and adjacent sequences, and within the C-terminal region. FREAC1/FREAC2 binding sequences are present in the promoters of several lung-specific genes, including CC10 and SPB (SFTPB). While both FREAC1 and FREAC2 transactivated an SPB promoter construct, CC10 was activated only by FREAC1. CC10 activation occurred specifically in a lung cell line with Clara cell-like characteristics.