Forkhead Box Protein J1 (FOXJ1)

FOXJ1 encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.The deduced 421-amino acid protein contains a central 101-amino acid forkhead domain. HFH4 shares about 91% amino acid identity with mouse and rat Hfh4, including 100% identity within the forkhead domain. Northern blot analysis of several adult and fetal tissues detected highest expression of a 2.5-kb transcript in adult testis. Lower levels were detected in adult ovary and lung and in fetal brain, lung, and kidney.