Forkhead Box Protein N3 (FOXN3)

FOXN3 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.Yeast 2-hybrid analysis of a fetal brain cDNA library revealed that the FOXN3 C-terminal domain interacted with SKIIP, a transcriptional coregulator that associates with repressor complexes. Coimmunoprecipitation analysis of epitope-tagged proteins confirmed the interaction in HeLa cells. Domain analysis revealed that the extreme C terminus of SKIIP interacted with the C-terminal domain of FOXN3.