Forkhead Box Protein Q1 (FOXQ1)

FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis. The genomic coordinates used for the transcript record were based on alignments. Human and mouse FOXQ1 share 78% amino acid identity. Within the forkhead domain, mouse, rat, and human FOXQ1 share 100% identity. Northern blot analysis revealed a 2.7-kb transcript in human gastric mucosa and in mouse stomach, but not in human gastric muscle. strong FOXQ1 expression in human stomach, trachea, bladder, and salivary gland, followed by duodenum, prostate, and fetal liver.