Forkhead Box Protein R2 (FOXR2)

Human FOXN6 gene was identified within human genome sequence RP11-167P23, mouse Foxn6 gene within mouse genome sequence RP23-180D16, and rat Foxn6 gene within rat genome sequence CH230-264B14 . FOXN6, RRAGB (RAGB), and KLF8 genes were clustered at human chromosome Xp11.21. Foxn6, Rragb, and Klf8 genes were also clustered at mouse chromosome XF3 as well as at rat chromosome Xq14. Human FOXN6 mRNA was expressed in breast cancer cell line and primary breast cancer. Mouse Foxn6 mRNA was expressed in E9.5 embryo. Human FOXN6 showed 57.7% total-amino-acid identity with human FOXN5, 53.8% total-amino-acid identity with mouse Foxn6 and 52.4% total-amino-acid identity with rat Foxn6. Codon 167-248 of human FOXN6 was the Forkhead domain.