Formin Homology 2 Domain Containing Protein 1 (FHOD1)

FHOD1 is a member of the formin/diaphanous family of proteins. FHOD1 is ubiquitously expressed but is found in abundance in the spleen. FHOD1 has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines.The full-length clone was obtained by screening a Burkitt lymphoma cell line and human fetal and adult spleen cDNA libraries with the partial cDNA. The deduced 1,165-amino acid protein has a calculated molecular mass of 128 kD and shows sequence homology to Diaphanous and FMN1 within the FH1 and FH2 domains.