Fragile Site, Folic Acid Type, Candidate 1 (FRA10AC1)

FRA10AC1 contains several sites for serine phosphorylation and a bipartite nuclear localization signal embedded within a larger lysine-rich region. Northern blot analysis detected a 1.45-kb transcript in all adult tissues examined. Strongest expression was in brain, heart, skeletal muscle, kidney, and liver. All other tissues expressed low levels of FRA10AC1 except leukocytes, in which expression was barely detectable. RT-PCR confirmed that FRA10AC1 is ubiquitously expressed and detected splice variants in some tissues, particularly in ovary and testis. The FRA10AC1 protein is conserved between species. The human protein shares 86% identity with mouse Fra10ac1 and about 35% identity with plant and C. elegans Fra10ac1. A central sequence of FRA10AC1 is most highly conserved.