Fruitless (FRU)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain.By EST database analysis, followed by PCR of a human B lymphoblastoid cell line cDNA library, Herberg et al. (1998) cloned ZBTB22, which they called BING1. The deduced 634-amino acid protein contains an N-terminal POZ/BTB domain and a C-terminal C2H2-type zinc finger domain.By genomic sequence analysis, Herberg et al. (1998) mapped the ZBTB22 gene to a gene cluster on chromosome 6p21.3 that includes tapasin .