G Antigen 13 (GAGE13)

GAGE cancer/testis antigens, including GAGE1, are frequently expressed in many different types of cancer, whereas their expression in normal tissues is limited to the germ cells of the immune-privileged organs, testis and ovary. The promoters, which are highly conserved within 1.4- to 1.5-kb of the transcription initiation site, are GC-rich and have no TATA boxes. GAGE transcripts are found only in primates.Gjerstorff and Ditzel (2008) stated that the GAGE13 gene is contained within a 9.5-kb GAGE repeat. The GAGE13 gene contains 5 exons spanning about 6.3 kb and has a LINE insertion.By genomic sequence analysis, Gjerstorff and Ditzel (2008) mapped the GAGE13 gene to a GAGE gene cluster on chromosome Xp11.23.