G Protein Alpha 15 (GNa15)

GNA11 and GNA16 genes in the human and the corresponding genes in the mouse are tandemly situated in both species, indicating that the tandem duplication occurred prior to the divergence of rodents and primates. The human gene is designated GNA15.mouse Gna15 and Edg6, which they designated Slp4, were coexpressed at the same relative levels in all tissues examined, with the highest expression in adult spleen and lung. They hypothesized that, due to their tandem chromosomal orientation as well as coexpression, the 2 genes may be under the control of the same enhancer elements, and the proteins may couple in vivo.GNA15 was able to bypass the usual selectivity of receptor G-protein interaction and nonselectively couple structurally and functionally diverse receptors to phospholipase C.