G Protein Beta 1 (GNb1)

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. GNb1 encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.The beta-subunit polypeptide, of relative molecular mass 37,375 Da, is encoded by a 2.9-kb mRNA. All mammalian tissues and clonal cell lines examined contained at least 2 beta-related mRNAs, usually 1.8 and 2.9 kb long. The authors suggested that there may be a diversity of beta subunit-related mRNAs that could encode different proteins.