G Protein Coupled Receptor 116 (GPR116)

GPR116 May have a role in the regulation of acid-base balance. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Exists as disulfide-linked dimers at the cell surface. 2 isoforms of the human protein are produced by alternative splicing. Ig-Hepta/GPR116 is a member of the LNB-TM7 subfamily of G protein–coupled receptors (GPCRs), also termed the adhesion GPCRs, whose members have EGF, cadherin, lectin, thrombospondin, or Ig repeats in their long N-terminus. The proEGF2 region is converted to EGF2 (52–223) by the processing enzyme furin and remains attached to the β- and γ-chains. Expression of some mRNA species was affected by the presence of α-fragment. These results suggest that the furin-processed α-fragment is involved in cellular signaling.