G Protein Gamma 2 (GNg2)

The full-length cDNA, obtained by 5-prime RACE, encodes a deduced 71-amino acid protein that is 100% homologous with the bovine, mouse, and rat GNG2 proteins.RT-PCR revealed expression in adult testis, adrenals, brain, white blood cells, and lung, but no or undetectable expression in testis from infertile or azoospermic patients, or in adult liver, muscle, or prostate. PCR of fetal tissues revealed highest expression in sternum and brain, intermediate expression in limbs, stomach, intestine, and kidney, and lowest expression in testis, heart, spleen, and lung. High expression was also found in tumor tissues from thyroid and parotid glands, in a squamous cell carcinoma, and in a lymphoid cell line, with little detected in granulation tissue.