G Protein Gamma 4 (GNg4)

G protein beta and gamma subunits directly regulate the activities of various enzymes and ion channels. For structural information about these proteins. The beta and gamma subunits belong to large multigene families. The beta subunits are highly conserved at the amino acid level, whereas the gamma subunits are more divergent.GNG4 encodes a deduced 75-amino acid protein, the sequence of which is 97% identical to the sequence of a putative mouse gamma-4 PCR fragment, 77% homologous to the sequence of gamma-2 subunit, and only 38% homologous to that of the gamma-1 subunit. By Northern blot analysis, GNG4 hybridized to a 7-kb species in skeletal muscle, a 5-kb species in brain, and a 2-kb species in brain, kidney, and pancreas. GNG4 was found to associate with the G protein beta-1 and beta-2 subunits.