G Protein Regulated Inducer Of Neurite Outgrowth 1 (GPRIN1)

GPRIN1 shares 46% amino acid identity with its mouse homolog.RT-PCR ELISA of specific brain regions detected high expression in cerebellum, followed by amygdala, hippocampus, substantia nigra, caudate nucleus, subthalamic nucleus, thalamus, and spinal cord, with low expression in corpus callosum.Northern blot analysis of human brain regions showed wide distribution in brain tissue and the central nervous system with highest expression in the spinal cord. Northern blot analysis of mouse tissues detected expression in brain only, and Western analysis detected protein in mouse neuroblastoma and rat pheochromocytoma cells. GPRIN1 and GNAO1 are membrane-bound proteins that are enriched in the growth cones of neurites.