GAS8 Antisense Gene Protein 1 (GAS8-AS1)

Loss of heterozygosity involving chromosome 16q24.3 is common in breast and prostate cancer and suggests the presence of a tumor suppressor gene. Whitmore et al. (1998) characterized a transcript located in the smallest region of deletion (GAS11). Within the second intron of the GAS11 gene, they discovered a second gene, C16ORF3 (chromosome 16 open reading frame 3), that is intronless, transcribed in the opposite orientation, and expressed at low levels. They performed mutational analysis by SSCA and could find no nucleotide base changes in either gene between 17 primary tumors and their corresponding matched normal DNA.25-kb GAS8 gene contains 11 exons separated by 10 introns. Intron 2 contains another gene, C16ORF3 (chromosome 16 open reading frame 3), which is intronless, transcribed in the opposite orientation, and expressed at low levels.