GINS Complex Subunit 2 (GINS2)

The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4), Psf1 (GINS1), Psf2, and Psf3 (GINS3). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts.By searching a human database for sequences similar to yeast Psf2, Takayama et al. (2003) identified GINS2, which they called PSF2. The deduced protein contains 185 amino acids.The International Radiation Hybrid Mapping Consortium mapped the GINS2 gene to chromosome 16.The GINS complex derives its name from the Japanese words Go, Ichi, Nii, and San, which mean 5, 1, 2, and 3, respectively, and refer to the numbering of the yeast homologs of the GINS complex.