GLIS Family Zinc Finger Protein 3 (GLIS3)

GLIS3 is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined.The deduced 774-amino acid human protein, which shares 86.2% identity with the mouse protein, contains 5 C2H2 zinc finger domains, interfinger Kruppel-like sequences, 2 proline-rich regions, and a bipartite nuclear localization signal (NLS).