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Артикул
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Наименование |
Производитель
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| E-AB-17980 |
E-AB-17980
GAB4 Polyclonal Antibody
Источник (хозяин): кролик
Реактивность подтвержденная: человек
Валидировано для:
IHC
Производитель:Elabscience
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Elabscience |
GRB2 Associated Binding Protein 4 (GAB4)
Английские синонимы
Growth factor receptor bound protein 2-associated protein 4; GRB2-associated binder 2-like; GRB2-associated binder 4; GRB2-associated-binding protein 2-like
GAB4 belongs to the GAB family.Contains 1 PH domain. Grb2-associated binder (Gab) family of scaffolding adaptor proteins coordinate signaling cascades downstream of growth factor and cytokine receptors. In the heart, among EGF family members, neuregulin-1beta (NRG-1beta, a paracrine factor produced from endothelium) induced remarkable tyrosine phosphorylation of Gab1 and Gab2 via erythroblastic leukemia viral oncogene (ErbB) receptors. Although DKO mice were viable, they exhibited marked ventricular dilatation and reduced contractility with aging. Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.
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