GTF2I Repeat Domain Containing Protein 2 (GTF2IRD2)

The human GTF2IRD2A protein contains 949 amino acids and has a calculated molecular mass of 107 kD. Its N-terminal half contains a leucine zipper motif, followed by 2 helix-loop-helix motifs (I repeats) that share homology with the TFII-I family of transcription factors. The C-terminal half of GTF2IRD2A contains a CHARLIE8 transposable element-like sequence, including 3 transposase-related domains that may be functional, and a BED zinc finger DNA-binding motif. The 949-amino acid GTF2IRD2B protein has 6 C-terminal amino acid changes relative to GTF2IRD2A. Northern blot and RT-PCR analyses of mouse tissues showed nearly ubiquitous expression of Gtf2ird2. No expression was detected in day-9.5 or -10.5 mouse embryos.