Gasdermin A (GSDMA)

GSDM showed apoptotic activity upon expression in a human gastric cancer cell line. LMO1, RUNX3), and TGF-beta receptor II (TGFBR2) were coexpressed with GSDM in pit cells, and both LMO1 and RUNX3 bound to the GSDM promoter in vitro. TGF-beta (TGFB1) upregulated LMO1 and GSDM expression and induced apoptosis, and induction of apoptosis was inhibited by suppression of LMO1, RUNX3, and GSDM expression. Saeki et al. (2007) concluded that GSDM is a component of TGF-beta signaling that induces apoptosis in gastric pit cells.The deduced 446-amino acid protein contains a leucine zipper motif. Northern blot analysis detected Gsdm1 expression in mouse stomach, skin, and esophagus, but not in other tissues examined. Northern blot analysis of human tissues detected GSDM1 expression in stomach only.