Germ Cell Less Homolog 1 (GMCL1)

GMCL1 encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein.Gmcl1 is known to be a nuclear lamina protein. Gmcl1 is RIPA-insoluble, so it"""s likely mgclh will also be RIPA-insoluble.  Protein size is expected to be around 55 kDa. The original literature on Gmcl1 said they resuspended the RIPA-insoluble pellet in "SDS-polyacrylamide gel electrophoresis sample buffer", but doesn"""t give the composition.