Glioblastoma Amplified Sequence (GBAS)

Chromosomal region 7p12, which contains GBAS, is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumor.The predicted 286-amino acid protein contains a signal peptide, a transmembrane domain, and 2 tyrosine phosphorylation sites. The GBAS transcript is expressed most abundantly in heart and skeletal muscle.GBAS protein might be involved in vesicular transport.The predicted 286-amino acid protein contains a signal peptide, a transmembrane domain, and 2 tyrosine phosphorylation sites. Northern blot analysis revealed that the 2.2-kb GBAS transcript is expressed in various tissues, most abundantly in heart and skeletal muscle.