Golgi Reassembly Stacking Protein 1 (GORASP1)

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis.GORASP1 protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined.The deduced 440-amino acid protein contains 2 N-terminal PDZ domains. Northern blot analysis detected variable expression of a 3.5-kb transcript in several tissues.