Gonadotropin Inducible Ovary Transcription Repressor 2 (GIOT2)

A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain. Bray et al. (1991) screened a placental genomic library at moderate stringency with a degenerate oligodeoxynucleotide probe designed to hybridize to the his/cys (H/C) link region between adjoining zinc fingers. Genomic clones were cross-hybridized with a set of 30 zinc finger-encoding cDNAs (KOX1-KOX30) isolated from a human T-cell cDNA library. KOX7 matched one of the genomic clones.Bray et al. (1991) mapped the ZNF44 gene to chromosome 16p11 by chromosomal in situ suppression hybridization with fluorescent probe detection.