H6 Family Homeobox Protein 3 (HMX3)

Hmx3 was expressed in a cell type-specific manner in rat salivary glands. Hmx3 was present in both the nuclei and cytoplasm of specific groups of duct cells of the submandibular, parotid, and sublingual glands.The deduced protein contains a C-terminal homeobox. In situ hybridization revealed that Nkx5.1 was first expressed in the developing ear, neural tube, and dorsal root ganglia. Expression was detected in discrete regions of the brain, with an anterior border in the ventral diencephalon at the optic chiasma and expression in mesencephalon, metencephalon, and myelencephalon. At midgestation, Nkx5.1 was also expressed in mesenchyme of the head and branchial arches and in some cranial ganglia, as well as in derivatives of neural crest, such as the truncus sympathicus and myenteric ganglia.