HD Domain Containing Protein 3 (HDDC3)
Английские синонимы
MESH1; ppGppase; Penta-Phosphate Guanosine-3"""-Pyrophosphohydrolase; Metazoan SpoT Homolog 1; Guanosine-3""",5"""-bis(diphosphate) 3"""-pyrophosphohydrolase MESH1
HDDC3 Belongs to the MESH1 family.Contains 1 HD domain. (p)ppGpp, guanosine pentaphosphate or tetraphosphate is an alarmone which is involved in the stringent response in bacteria, causing the inhibition of RNA synthesis when there is a shortage of amino acids present. This causes translation to decrease and the amino acids present are therefore conserved. Furthermore, genes for amino acid uptake (transport into the cell from surrounding media) and biosynthesis are also upregulated. However, (p)ppGpp influences the overall gene expression pattern in the cell so that many genes required for survival in stressful conditions are up-regulated. (p)ppGpp is created via pppGpp synthase, also known as RelA, and is converted from pppGpp to ppGpp via pppGpp phosphohydrolase.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
