Heat Shock 70kDa Protein 12A (HSPA12A)

Heat shock 70kDa protein 12A is a member of the Hsp70 family of heat shock proteins.The deduced protein contains 710 amino acids. HSPA12A expression in brain, followed by kidney, testis, and ovary. Little to no expression was detected in other tissues examined. In vitro translated HSPA12A had an apparent molecular mass of 73 kD by SDS-PAGE. The 675-amino acid human protein shares 96% identity with mouse Hspa12a and 60% identity with human HSPA12B. Northern blot analysis of human tissues detected highest expression of a 6.5-kb transcript in brain, with progressively lower levels in kidney, skeletal muscle, and heart. Mouse Hspa12a showed a similar expression pattern, but it was not expressed in skeletal muscle.