Homeobox Protein A7 (HOXA7)

HOXA7 is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.MIRN10A was downregulated in differentiated megakaryocytes, whereas HOX1A protein and mRNA were upregulated during megakaryocytic differentiation. Transfection of human megakaryocytic or myelogenous leukemia cell lines with MIRN10A precursor reduced expression of a reporter gene containing the 3-prime UTR of HOXA1 and reduced HOXA1 protein levels.