Homeobox Protein B13 (HOXB13)

HOXB13 encodes a transcription factor that belongs to the homeobox gene family. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.The 60-amino acid homeodomain near the C terminus of HOXB13 shares 78 to 83% identity with HOX proteins in paralog group-13 of the AbdB subfamily; 6 of the amino acid differences from other members of this group represent conservative changes. Moreover, HOXB13 shares less than 60% identity with other AbdB-related genes.