IKAROS Family Zinc Finger Protein 2 (IKZF2)

IKZF2 encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.Sequence analysis predicted that the 526-amino acid human protein, which is 97% identical to the mouse protein, contains 4 N-terminal zinc fingers that compose the DNA-binding domain, and 2 C-terminal zinc fingers that mediate protein dimerization.