Importin 11 (IPO11)

Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors that mediate nucleocytoplasmic transport of protein and RNA cargoes .The deduced 975-amino acid protein shares 24% amino acid identity with S. cerevisiae Lph2 protein.IPO11 increased nuclear accumulation of RPL12 in a RAN-dependent manner, and overexpression of an IPO11 mutant lacking the RAN-binding domain did not increase nuclear accumulation of RPL12. In vitro binding assay showed that IPO11 did not bind RPL23A, and transient transfection assay showed that importin-beta and IPO5 (RANBP5) had no effect on nucleocytoplasmic distribution of RPL12, indicating that IPO11 is a specific nuclear import receptor for RPL12.