InaD Like Protein (INADL)

INADL encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.A 75-kD protein was present in both membrane and cytosolic fractions of Caco-2 cells. Immunoelectron microscopy localized INDAL near tight junctions in human colon and Caco-2 cells, often on the apical side, and also beneath the apical plasma membrane and in microvilli.