Inositol-1,4,5-Trisphosphate Receptor Type 2 (ITPR2)

The complete nucleotide sequences for both receptors were determined. The human type 2 (ITPR2) and type 3 (ITPR3) receptors are 2,710 amino acids and 2,671 amino acids long, respectively, and have significant sequence homologies as well as structural similarities, including the 6 membrane-spanning regions near the C termini.Calcium flicker activity is dually coupled to membrane tension, by means of TRPM7, a stretch-activated calcium-permeant channel of the transient receptor potential superfamily, and chemoattractant signal transduction, by means of type 2 inositol-1,4,5-triphosphate receptors. Interestingly, calcium flickers are most active at the leading lamella of migrating cells, displaying a 4:1 front-to-rear polarization opposite to the global calcium gradient.