Intraflagellar Transport Protein 81 (IFT81)

The splice sites conformed to the GT-AG rule, and the CDV1R mRNA containing 19 exons is processed. CDV1 mRNA containing 5 exons was constructed from the 3-prime half of CDV1R.The first exon of CDV1 consists of the 3-prime side (116 bp) of intron 14 and exon 15 (87 bp) of CDV1R. The presumed promoter sequence for CDV1, located in intron 14 of CDV1R, contains the common TATA box and consensus binding sites for various transcription factors that seem to play roles in the heart-specific expression and carnitine deficiency-associated suppression of CDV1. The authors thus showed that 2 mRNA species, CDV1 and CDV1R, are expressed tissue specifically by using promoters peculiar to each transcript in a single gene.